Octanoic Acid → Isosorbide dicaprylate

HRID 61933

반응식

HRID 61933 반응식
[CH2:1]1[O:5][C@@H:4]2[C@@H:6]([OH:9])[CH2:7][O:8][C@@H:3]2[C@@H:2]1[OH:10].[C:11]([OH:20])(=O)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>O>[CH3:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C:11]([O:10][C@H:2]1[C@H:3]2[O:8][CH2:7][C@H:6]([O:9][C:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])=[O:20])[C@H:4]2[O:5][CH2:1]1)=[O:20]

참가 물질

4

반응물 2

HCID 379Octanoic AcidHCID 12597Isosorbide

생성물 1

HCID 10501064Isosorbide dicaprylate

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
180 °C

실험 절차

In a stirred 1 liter apparatus under a stream of nitrogen, 219.0 g (1.5 mol) of isosorbide and 461.4 g (3.2 mol) of caprylic acid are heated with stirring and under a stream of nitrogen to 180° C. The reaction mixture was heated at 180° C. until no more water of reaction distilled off (about 28 h). The temperature was then gradually increased to 210° C. (altogether over about 30 h). The reaction has ended when a residual acid value of <2 mg KOH/g is reached. This gives a clear red-brown solution.

후처리

  1. distillationdistilled off (about 28 h)
  2. temperatureThe temperature was then gradually increased to 210° C. (altogether over about 30 h)
  3. customThis gives a clear red-brown solution

출처 및 근거

ORD 기록
ord-ac5a0278a69c441dbf19270139a5121e
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09445595B2

연결된 노트

불러오는 중…