1-Chloromethylnaphthalene → 1-Naphthaleneacetonitrile

HRID 619349

반응식

HRID 619349 반응식
Cl[CH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1.[C-:13]#[N:14].[K+]>CN(C=O)C.[I-].[K+]>[C:3]1([CH2:2][C:13]#[N:14])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1

참가 물질

5

반응물 2

HCID 68451-ChloromethylnaphthaleneHCID 9032Potassium Cyanide

생성물 1

HCID 85961-Naphthaleneacetonitrile수율 98%

시약·촉매·용매 2

HCID 4875Potassium Iodide촉매HCID 6228Dimethylformamide용매

실험 절차

1-Chloromethyinaphthalene (5.00 ml, 33 mmol) was dissolved in N,N'-dimethylformamide (50 ml) and potassium cyanide (4.31 g, 66 mmol) and potassium iodide (0.1 g) were added and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was partitioned between water (150 ml) and diethyl ether (2×100 ml). The combined organic phases were washed with water (100 ml), dried (MgSO4), filtered and concentrated in vacuo affording 5.41 g (98%) of 1-naphtylacetonitrile as an oil.

후처리

  1. customThe reaction mixture was partitioned between water (150 ml) and diethyl ether (2×100 ml)
  2. washThe combined organic phases were washed with water (100 ml)
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-de3f8fa39a1048f5b83f53a4b54780a8
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05958957

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