3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid → 2-(3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-8-methyl-4H-benzo[d][1,3]oxazin-4-one

HRID 61945

반응식

HRID 61945 반응식
[Br:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=O)[N:4]([C:10]2[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][N:11]=2)[N:3]=1.[NH2:17][C:18]1[C:26]([CH3:27])=[CH:25][C:24]([Cl:28])=[CH:23][C:19]=1[C:20](O)=[O:21]>>[Br:1][C:2]1[CH:6]=[C:5]([C:7]2[O:9][C:20](=[O:21])[C:19]3[CH:23]=[C:24]([Cl:28])[CH:25]=[C:26]([CH3:27])[C:18]=3[N:17]=2)[N:4]([C:10]2[C:15]([Cl:16])=[CH:14][CH:13]=[CH:12][N:11]=2)[N:3]=1

참가 물질

3

반응물 2

HCID 115875353-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid2회HCID 116440442-Amino-5-chloro-3-methylbenzoic acid2회

생성물 1

HCID 102533072-(3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)-6-chloro-8-methyl-4H-benzo[d][1,3]oxazin-4-one

실험 절차

A procedure analogous to that of Example 1, Step E was used to convert 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid (i.e. the pyrazolecarboxylic acid product of Example 5, Step D) (1.5 g, 4.96 mmol) and 2-amino-3-methyl-5-chlorobenzoic acid (i.e. the product of Example 1 Step A) (0.92 g, 4.96 mmol) to the title product as a solid (1.21 g).

출처 및 근거

ORD 기록
ord-699c74e87b284d078841618d35948274
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09445593B1

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