Potassium Carbonate → 4-Chloro-5-(5-isoquinolylsulfanyl)-2-nitroaniline

HRID 619729

반응식

HRID 619729 반응식
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([SH:11])[C:5]=2[CH:4]=[CH:3][N:2]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:18][C:19]1[C:25](Cl)=[CH:24][C:22]([NH2:23])=[C:21]([N+:27]([O-:29])=[O:28])[CH:20]=1>CN(C=O)C>[Cl:18][C:19]1[C:25]([S:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][N:2]=[CH:1]3)=[CH:24][C:22]([NH2:23])=[C:21]([N+:27]([O-:29])=[O:28])[CH:20]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 811494,5-Dichloro-2-nitroanilineHCID 110519635-Isoquinolinethiol

생성물 1

HCID 218469034-Chloro-5-(5-isoquinolylsulfanyl)-2-nitroaniline수율 98.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5-Isoquinolinethiol 500 mg (3.1 mmol) was dissolved in DMF 15 ml, potassium carbonate 830 mg (6.0 mmol) and 4,5-dichloro-2-nitroaniline 620 mg (3.0 mmol) were added, and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into ice water, and the resulting precipitates were collected and washed with water to give 4-chloro-5-(5-isoquinolylsulfanyl)-2-nitroaniline 980 mg (98.4%).

후처리

  1. customthe resulting precipitates
  2. customwere collected
  3. washwashed with water

출처 및 근거

ORD 기록
ord-2aa0d5973a264f50a9117edd28e1e3fd
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05959107

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