Triethylamine → N2,N7-bis(4-tert-butylcyclohexyl)-9,10-dioxo-9,10-dihydroanthracene-2,7-disulfonamide

HRID 61978

반응식

HRID 61978 반응식
[CH:1]1[C:14]2[C:13](=[O:15])[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([S:16](Cl)(=[O:18])=[O:17])[CH:11]=3)[C:6](=[O:20])[C:5]=2[CH:4]=[CH:3][C:2]=1[S:21](Cl)(=[O:23])=[O:22].[C:25]([CH:29]1[CH2:34][CH2:33][CH:32]([NH2:35])[CH2:31][CH2:30]1)([CH3:28])([CH3:27])[CH3:26].C([N:38]([CH2:41][CH3:42])CC)C>C(Cl)Cl>[C:25]([CH:29]1[CH2:30][CH2:31][CH:32]([NH:35][S:21]([C:2]2[CH:3]=[CH:4][C:5]3[C:6](=[O:20])[C:7]4[C:12](=[CH:11][C:10]([S:16]([NH:38][CH:41]5[CH2:42][CH2:34][CH:29]([C:25]([CH3:28])([CH3:27])[CH3:26])[CH2:30][CH2:31]5)(=[O:18])=[O:17])=[CH:9][CH:8]=4)[C:13](=[O:15])[C:14]=3[CH:1]=2)(=[O:23])=[O:22])[CH2:33][CH2:34]1)([CH3:28])([CH3:26])[CH3:27]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 793964-tert-ButylcyclohexylamineHCID 234366039,10-Dioxo-9,10-dihydro-anthracene-2,7-disulfonyl dichloride

생성물 1

HCID 46851178N2,N7-bis(4-tert-butylcyclohexyl)-9,10-dioxo-9,10-dihydroanthracene-2,7-disulfonamide수율 95%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
-50 °C

실험 절차

Anthraquinone-2,7-disulfonylchloride (10 g, 24.7 mmol)) was dissolved in 200 mL DCM. The solution was cooled to −50° C. To this solution was added 4-tert-butylcyclohexanamine (8.43 g, 54 mmol), followed by triethyl amine (8.6 ml, 61.7 mmol). The reaction mixture was stirred at room temperature for 4 hrs. Solvent was evaporated and the residue was treated with MeOH, filtered off, and dried to obtain 15 g (95%) of the product (1-36) as yellow powder.

후처리

  1. customSolvent was evaporated
  2. additionthe residue was treated with MeOH
  3. filtrationfiltered off
  4. customdried

출처 및 근거

ORD 기록
ord-e94f88dfad7944568fb1165923aa7c7f
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09446021B2

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