4-(Bromomethyl)picolinonitrile → [1-(2-Cyano-pyridin-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]carbamic acid tert-butyl ester

HRID 619856노트

반응식

HRID 619856 반응식
[C:1]([O:5][C:6](=[O:14])[NH:7][C@H:8]1[CH2:12][CH2:11][NH:10][C:9]1=[O:13])([CH3:4])([CH3:3])[CH3:2].[C:15]([C:17]1[CH:22]=[C:21]([CH2:23]Br)[CH:20]=[CH:19][N:18]=1)#[N:16]>>[C:1]([O:5][C:6](=[O:14])[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([CH2:23][C:21]2[CH:20]=[CH:19][N:18]=[C:17]([C:15]#[N:16])[CH:22]=2)[C:9]1=[O:13])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 106317764-(Bromomethyl)picolinonitrileHCID 10750535(S)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamate

생성물 1

HCID 10829192[1-(2-Cyano-pyridin-4-ylmethyl)-2-oxopyrrolidin-3-(S)-yl]carbamic acid tert-butyl ester

실험 절차

The title compound is prepared from (2-oxopyrrolidin-3-(S)-yl)-carbamic acid tert-butyl ester as described in EXAMPLE 122, Part F using 2-cyano-4-(bromomethyl)pyridine in place of 4-bromomethylthiophene-2-carbonitrile. The crude product is purified by column chromatography eluting with gradient of 25% EtOAc/CH2Cl2 to 50% EtOAc/CH2Cl2 to afford the title compound as a solid.

후처리

  1. customThe crude product is purified by column chromatography
  2. washeluting with gradient of 25% EtOAc/CH2Cl2 to 50% EtOAc/CH2Cl2

출처 및 근거

ORD 기록
ord-b8c89eeff8dc46c5a1678e149c6cb36a
출처 데이터셋
uspto-grants-1999_09
특허 번호
US05958918

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