Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Vanillin → (Z)-3-(4-hydroxy-3-methoxyphenyl)-2-(6-(trifluoromethyl)pyridin-3-yl)acrylonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Vanillin | HCID 1183 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (Z)-3-(4-hydroxy-3-methoxyphenyl)-2-(6-(trifluoromethyl)pyridin-3-yl)acrylonitrile | HCID 68702729 | — |
반응 단계
A suspension of vanillin (1.0 g, 6.57 mmol), 2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile (1.222 g, 6.57 mmol) and piperidine (0.71 mL, 7.23 mmol) in absolute ethanol (10 mL) was stirred at reflux for forty-eight hours and then allowed to cool to room temperature. The resulting precipitate was filtered off, washed with water and dried. Recrystallisation from isopropanol afforded (Z)-3-(4-hydroxy-3-methoxyphenyl)-2-(6-(trifluoromethyl)pyridin-3-yl)acrylonitrile as white crystals, 0.904 g (43%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09446012B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-7bdeba46afee4b3db38f154b9a558d15 |
| 출처 메모 | uspto-grants-2016_09 |