2-Nitropropane → HCID 14478920, 화합물

HRID 620005노트

반응식

HRID 620005 반응식
C[O-].[Na+].[N+](C(C)C)([O-])=[O:5].[CH3:10][C:11]1[C:18]([CH2:19]Br)=[CH:17][CH:16]=[C:15]([NH:21][C:22](=[O:24])[CH3:23])[C:12]=1[C:13]#[N:14]>CO>[C:22]([NH:21][C:15]1[CH:16]=[CH:17][C:18]([CH:19]=[O:5])=[C:11]([CH3:10])[C:12]=1[C:13]#[N:14])(=[O:24])[CH3:23]

참가 물질

5

반응물 3

HCID 3982-NitropropaneHCID 10942334Sodium MethoxideHCID 14478919HCID 14478919, 화합물

생성물 1

HCID 14478920HCID 14478920, 화합물수율 53%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of sodium methoxide, 0.43 g, in 100 ml of methanol, was added 0.84 g of 2-nitropropane. After 15 min, 2 g of 2-methyl-3-bromomethyl-6-acetamidobenzonitrile was added and the resulting solution was stirred for 2.5 h at ambient temperature. The solvent was then evaporated at reduced pressure and the residue dissolved in chloroform. The chloroform solution was filtered, washed with H2O, dried and the solvent removed at reduced pressure. The residue was crystallized from chloroform-carbon tetrachloride to yield 0.8 g (53%) of product, m.p. 170°-173° C. NMR (CDCl3) 2.30 (3H, s, CH3CO--N), 2.90 (3H, s, CH3), 8.00 (1H, d, C--5H), 8.6 (1H, d, C--6H), 10.20 (1H, s, (CHO)d. Anal. calc'd for CH11H10N2O2.1/3H2O: C, 63.5; H, 4.84; N, 13.5. Found: C, 63.4; H, 5.00; N, 13.7.

후처리

  1. customThe solvent was then evaporated at reduced pressure
  2. dissolutionthe residue dissolved in chloroform
  3. filtrationThe chloroform solution was filtered
  4. washwashed with H2O
  5. customdried
  6. customthe solvent removed at reduced pressure
  7. customThe residue was crystallized from chloroform-carbon tetrachloride

출처 및 근거

ORD 기록
ord-7119c987ffdf4914bbf95d3170801949
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04818753

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