4-Aminopyridine → HCID 14456465, 화합물

HRID 620035노트

반응식

HRID 620035 반응식
[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[CH2:17]Cl)[CH:5]=[CH:6][CH:7]=1.[NH2:19][C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=[C:9]2[CH2:17][NH:19][C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 17274-AminopyridineHCID 212484162-(chloromethyl)-1-(3-fluorophenyl)-1H-1,3-benzodiazole

생성물 1

HCID 14456465HCID 14456465, 화합물수율 20.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A ethanol (8 ml) solution of 1-(3-fluorophenyl)-2-chloromethylbenzimidazole (1.0 g, 4 mmol) prepared in the preceding step (b) and 4-aminopyridine (1.3 g, 7.4 mmol) was refluxed for 1.5 hours. The reaction mixture was concentrated in vacuo and crystallized from acetone and recrystallized from ethanol-acetone, then the objective compound (0.3 g, 0.82 mmol) was obtained.

후처리

  1. temperaturewas refluxed for 1.5 hours
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customcrystallized from acetone
  4. customrecrystallized from ethanol-acetone

출처 및 근거

ORD 기록
ord-c19ce065174e41bfa6121f39389b6ce6
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04818761

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