Acetic Acid → 1-Phenyl-4-(cyclohexyl-sulfinyl)-5-chloropyridazin-6-one

반응식

OO.[C:3]1([N:9]2[C:14](=[O:15])[C:13]([Cl:16])=[C:12]([S:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[CH:11]=[N:10]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(O)(=[O:26])C>O>[C:3]1([N:9]2[C:14](=[O:15])[C:13]([Cl:16])=[C:12]([S:17]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[O:26])[CH:11]=[N:10]2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

실험 절차

5.1 parts by volume of 30% strength by weight hydrogen peroxide were added dropwise to a solution of 16 parts by weight of 1-phenyl-4-(cyclohexylthio)-5-chloropyridazin-6-one in 100 parts by volume of glacial acetic acid, and stirring was continued for 12 hours at 60° C. The reaction mixture was then stirred into 1,000 parts by volume of water, and the precipitate was filtered off under suction, washed with water and dried under reduced pressure. 16.3 parts by weight of 1-phenyl-4-(cyclohexyl-sulfinyl)-5-chloropyridazin-6-one of melting point 128°-130° C. were obtained (compound No.1).