Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 4-Chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-Pyrimidinemethanol,5-methyl-6-(1-piperidinyl)- | HCID 14306162 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 4-Chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride | HCID 21245798 | — |
반응 단계
Thionyl chloride (4.5 ml) in chloroform (30 ml) was added dropwise to a stirred solution of 4-hydroxymethyl-5-methyl-6-piperidinopyrimidine (4.24 g) in chloroform (30 ml) cooled in an ice-salt bath. The mixture was allowed to warm to room temperature and stirred for a further 22 hours. The solution was stripped to a residual glass which was triturated with diethyl ether to give 4-chloromethyl-5-methyl-6-piperidino-pyrimidine hydrochloride, 5.24 g, m.p. 182°-184°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04820708 |
| 출처 데이터셋 | uspto-grants-1989_04 |
| ORD ID | ord-47cbc3b89caa4caaa7e580236d6fee8b |
| 출처 메모 | uspto-grants-1989_04 |