Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-(Diethylamino)-2-(naphthalen-1-yl)butanenitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 1-Naphthaleneacetonitrile | HCID 8596 | — |
| 반응물 | Diethylaminoethyl chloride | HCID 13364 | — |
| 반응물 | Sodium amide | HCID 24533 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 4-(Diethylamino)-2-(naphthalen-1-yl)butanenitrile | HCID 17395 | — |
반응 단계
7 g of sodium amide are added in small quantities to 27.11 g of 1-naphthylacetonitrile in 210 ml of anhydrous benzene. The mixture is heated for 2 hours to reflux and 22 g of 2-chlorodiethylaminoethane are added, the heating being continued to reflux for another two and a half hours. Then, the mixture is cooled and 200 ml of water are added. After decanting, the organic phase is extracted by HCl at 10%. The aqueous phase is washed in ether, neutralized with NaOH at 10%, then extracted with ether. After evaporation of the solvents, a red oil is obtained, which is distilled in vacuo.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04820717 |
| 출처 데이터셋 | uspto-grants-1989_04 |
| ORD ID | ord-4f69d616f8da4d33875e10cd41f600d6 |
| 출처 메모 | uspto-grants-1989_04 |