Nitric Acid → HCID 178526762, 화합물

HRID 62025

반응식

HRID 62025 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([OH:11])=[CH:3][CH:2]=1.[N+:12]([O-])([OH:14])=[O:13]>C(O)(=O)CC.C(O)C>[N+:12]([C:3]1[CH:2]=[N:1][C:10]2[C:5]([C:4]=1[OH:11])=[CH:6][CH:7]=[CH:8][CH:9]=2)([O-:14])=[O:13]

참가 물질

5

반응물 2

HCID 944Nitric AcidHCID 178516385quinolin-4-ol

생성물 1

HCID 178526762HCID 178526762, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 1032Propionic Acid용매

반응 조건

온도
125 °C

실험 절차

A mixture of quinolin-4-ol (1 eq.) in propionic acid was heated to 125° C. with stirring. Nitric acid (2.2 eq.) was added drop wise to the stirred solution while maintaining the reaction mixture temperature at 125° C. Reaction was stirred at 125° C. for 15 min. and cooled to ambient temperature. The reaction was diluted with ethanol and solid was collected by vacuum filtration. Solid was washed successively with ethanol, water and ethanol. Resulting yellow solid was heated in refluxing ethanol and filtered from hot mixture to give pure 3-nitro-quinoline-4-ol.

후처리

  1. temperaturewhile maintaining the reaction mixture temperature at 125° C
  2. customReaction
  3. stirringwas stirred at 125° C. for 15 min.
  4. temperaturecooled to ambient temperature
  5. filtrationwas collected by vacuum filtration
  6. washSolid was washed successively with ethanol, water and ethanol
  7. customResulting yellow solid
  8. temperaturewas heated
  9. filtrationfiltered from hot mixture

출처 및 근거

ORD 기록
ord-e3929725edc44b4791055f004d72daca
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09446040B2

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