Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 620289생성일: 2026년 10월 24일
Acetone → 4-amino-5-chloro-2-[2-(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide hydrochloride monohydrate
https://huagongshe.com/ko/reaction/620289
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-(2-(methylsulfinyl)ethoxy)benzamide | HCID 9822947 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 4-amino-5-chloro-2-[2-(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide hydrochloride monohydrate | HCID 21245862 | — |
반응 단계
A mixture of 4-amino-5-chloro-2[2-(methylsulfinyl)ethoxy]-N-[2-(diethylamino)ethyl]benzamide (84.50 g, 22.5 mmoles), acetone (592 ml) and 2-propanol (169 ml) was stirred and warmed until complete solution (ca. 25° C.) and then 56.2 ml of 4N HCl (1 equivalent) was all at once. The temperature rose to 32° C. After one hour at ambient temperature the mixture was stored at 0° C. for 18 hours. The hydrochloride salt was collected by filtration, rinses with acetone and dried in vacuo over P2O5 for six hours. Yield: 89.6 g (96.6%); mp 117°-124° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04820715 |
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| 출처 데이터셋 | uspto-grants-1989_04 |
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| ORD ID | ord-0cdd82d3d03e4f99b4b7d037fb45ca38 |
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| 출처 메모 | uspto-grants-1989_04 |
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