Triethylamine → HCID 21243981, 화합물

HRID 620680

반응식

HRID 620680 반응식
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([OH:23])=[O:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.[O:24]1[C:26]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:25]1.C(N(CC)CC)C>O1CCCC1.C(Cl)Cl>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([O:23][CH2:25][CH:26]([OH:24])[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:22])=[CH:19][CH:20]=2)=[CH:11][CH:10]=1

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 14299145Epoxy-styreneHCID 22242497HCID 22242497, 화합물

생성물 1

HCID 21243981HCID 21243981, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 26.6 g of 4'-(6-hydroxyhexyloxy)(1,1')-biphenyl-4-carboxylic acid, 16 g of epoxystyrene and 16 g of triethylamine in 300 ml of tetrahydrofuran is heated at the boiling point for 140 hours. It is diluted with 1000 ml of methylene chloride, washed twice with 2N hydrochloric acid and dried over sodium sulfate. After concentration under reduced pressure, the residue is crystallized from ethanol. 2-Hydroxy-2-phenylethyl 4'-(6-hydroxyhexyloxy)-(1,1')-biphenyl-4-carboxylate is obtained; melting point: 148°-150°.

후처리

  1. washwashed twice with 2N hydrochloric acid
  2. dry with materialdried over sodium sulfate
  3. concentrationAfter concentration under reduced pressure
  4. customthe residue is crystallized from ethanol

출처 및 근거

ORD 기록
ord-eed9bfa7fce04b72ba6f37a25675ea79
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04822682

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