Kojic Acid → 5-(benzhydryloxy)-2-(hydroxymethyl)-4H-pyran-4-one

HRID 620748노트

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HRID 620748 반응식
[CH:1]1[C:6](=[O:7])[C:5]([OH:8])=[CH:4][O:3][C:2]=1[CH2:9][OH:10].[C:11]1([C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N+]=[N-])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[CH:17]([O:8][C:5]1[C:6](=[O:7])[CH:1]=[C:2]([CH2:9][OH:10])[O:3][CH:4]=1)([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 3840Kojic AcidHCID 612301,1'-(Diazomethylene)bis(benzene)

생성물 1

HCID 143063875-(benzhydryloxy)-2-(hydroxymethyl)-4H-pyran-4-one수율 56.8%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
60 °C

실험 절차

14.2 g (0.1 mol) of kojic acid was added to ethanol (400 ml), and heated to 60° C. and dissolved. After cooling the solution to room temperature, 29.1 g (0.15 mol) of diphenyldiazomethane was added thereto, and the mixture was reacted at room temperature for 18 hours under stirring. The reaction solution was concentrated to dryness, and benzene (300 ml) was added thereto. Then, insolubles were removed by filtration. To the filtrate, water (300 ml) was added, and the precipitates thereby formed were collected by filtration, and washed with benzene to obtain 17.5 g (yield: 56.8%) of the above identified compound.

후처리

  1. dissolutiondissolved
  2. temperatureAfter cooling the solution to room temperature
  3. customthe mixture was reacted at room temperature for 18 hours
  4. concentrationThe reaction solution was concentrated to dryness, and benzene (300 ml)
  5. additionwas added
  6. customThen, insolubles were removed by filtration
  7. additionTo the filtrate, water (300 ml) was added
  8. customthe precipitates
  9. customthereby formed
  10. filtrationwere collected by filtration
  11. washwashed with benzene
  12. customto obtain 17.5 g (yield: 56.8%) of the

출처 및 근거

ORD 기록
ord-0d20fde715874a0682073c7edb4e81de
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04822786

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