2-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanol → 2-[(3-Pyrrolidinylmethyl)amino]ethanol

HRID 620861

반응식

HRID 620861 반응식
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[NH:8]1[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]1

참가 물질

5

반응물 2

HCID 142808882-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 134918032-[(3-Pyrrolidinylmethyl)amino]ethanol수율 57.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 32.3 g of 2-[[[1-(phenylmethyl)-3-pyrrolidinyl]methyl]amino]ethanol, 330 ml of methanol and 3 g of 20% palladium on charcoal was shaken in an atmosphere of hydrogen at about 4.5×105Pa and at room temperature for 18 hours. The solvents were then removed at reduced pressure. The residue was distilled under vacuum (bp 129°-131° C., 1.5 mm Hg) to give 11.43 g of 2-[(3-pyrrolidinylmethyl)amino]ethanol.

후처리

  1. customThe solvents were then removed at reduced pressure
  2. distillationThe residue was distilled under vacuum (bp 129°-131° C., 1.5 mm Hg)

출처 및 근거

ORD 기록
ord-57eb0aa3de4f4e9d8d22f350d3256450
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04822801

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