홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

p-Toluenesulfonic acid monohydrate → (3R,4S)-3-[2-(2-chloroacetamidothiazol-4-yl)-2-methoxyiminoacetamido]-4-(1-methyl-1H-tetrazol-4-yl)thio-2-oxoazetidine

HRID 620997
노트
인쇄 미리보기

반응식

HRID 620997 반응식
[CH3:1][N:2]1[CH2:6][N:5]([S:7][C@@H:8]2[NH:11][C:10](=[O:12])[C@H:9]2[NH:13]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:4]=[N:3]1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1.[Cl:45][CH2:46][C:47]([NH:49][C:50]1[S:51][CH:52]=[C:53]([C:55](=[N:59][O:60][CH3:61])[C:56]([OH:58])=O)[N:54]=1)=[O:48]>CC(C)=O>[Cl:45][CH2:46][C:47]([NH:49][C:50]1[S:51][CH:52]=[C:53]([C:55](=[N:59][O:60][CH3:61])[C:56]([NH:13][C@H:9]2[C@H:8]([S:7][N:5]3[CH2:6][N:2]([CH3:1])[N:3]=[N:4]3)[NH:11][C:10]2=[O:12])=[O:58])[N:54]=1)=[O:48]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 521998p-Toluenesulfonic acid monohydrateHCID 581157C8H8ClN3O4SHCID 54359258(3R,4S)-4-(1-methyl-1H-tetrazol-4-yl)thio-3-tritylamino-2-oxoazetidine

생성물 1

HCID 57003025(3R,4S)-3-[2-(2-chloroacetamidothiazol-4-yl)-2-methoxyiminoacetamido]-4-(1-methyl-1H-tetrazol-4-yl)thio-2-oxoazetidine수율 55.9%

시약·촉매·용매 1

HCID 180
Acetone
용매

실험 절차

Following the procedure of Reference Example 66B, solution of 1.12 g of (3R,4S)-4-(1-methyl-1H-tetrazol-4-yl)thio-3-tritylamino-2-oxoazetidine in 5 ml of acetone, 0.491 g of p-toluenesulfonic acid monohydrate and 0.788 g of 2-(2-chloroacetamidothiazol-4-yl)-2-methoxyiminoacetic acid is treated to give 0.650 g of (3R,4S)-3-[2-(2-chloroacetamidothiazol-4-yl)-2-methoxyiminoacetamido]-4-(1-methyl-1H-tetrazol-4yl)thio-2oxoazetidine.

후처리

  1. additionis treated

출처 및 근거

ORD 기록
ord-87090f6a87354e1f85f375d0c9e04092
출처 데이터셋
uspto-grants-1989_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04822790

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트