3,4,5-Trimethoxyaniline → 9-(3,4,5-Trimethoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

참여 물질

역할	이름	HCID	투입량
반응물	3,4,5-Trimethoxyaniline	HCID 32285	—
반응물	Potassium Bromide	HCID 253877	—
반응물	HCID 178484237	HCID 178484237	—
용매	Dichloromethane ethylacetate	HCID 21226138	—
생성물	9-(3,4,5-Trimethoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile	HCID 71277814	94%

반응 단계

Prepared from VII and 3,4,5-trimethoxyaniline. Flash chromatography eluent (DCM-EtOAc, 5:5). Yield: 94%; pale yellow solid, mp 230° C.; IR (KBr) νmax/cm−1 3255, 3089, 3001, 2947, 2837, 2230, 1735, 1637, 1613, 1581, 1498, 1458, 1412, 1381, 1352, 1307, 1270, 1229, 1193, 1165, 1122, 1037, 1002, 991, 970, 952, 852, 830; 1H NMR (300 MHz, DMSO-d6) δ 8.51 (d, 1H, J=9.0 Hz), 8.05 (s, 1H), 7.80 (d, 1H, J=9.0 Hz), 6.46 (s, 2H), 3.77 (s, 6H), 3.67 (s, 3H); HRMS calcd for C19H16N5O3S (M+H+): 394.0974, found 394.0987.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09446044B2
출처 데이터셋	uspto-grants-2016_09
ORD ID	ord-0e8f9e87300b45a38d39e55d45eddd61
출처 메모	uspto-grants-2016_09