Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Bromide → 9-(4-Bromobenzo[d][1,3]dioxol-5-ylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Bromide | HCID 253877 | — |
| 반응물 | 2-Bromo-3,4-(methylenedioxy)aniline | HCID 89415048 | — |
| 반응물 | HCID 178484237 | HCID 178484237 | — |
| 용매 | Dichloromethane ethylacetate | HCID 21226138 | — |
| 생성물 | 9-(4-Bromobenzo[d][1,3]dioxol-5-ylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile | HCID 71277754 | 21% |
반응 단계
Prepared from VII and 2-bromo-3,4-(methylenedioxy)aniline. Flash chromatography eluent (DCM-EtOAc, 5:5). Yield: 21%; yellow solid, mp>260° C.; IR (KBr) νmax/cm−1 2887, 2233, 1632, 1610, 1581, 1501, 1484, 1465, 1379, 1348, 1303, 1267, 1232, 1161, 1116, 1034, 970, 929, 829; 1H NMR (300 MHz, DMSO-d6) δ 8.49 (d, 1H, J=9.0 Hz), 8.06 (s, 1H), 7.77 (d, 1H, J=9.0 Hz), 7.25 (s, 1H), 6.83 (s, 1H), 6.06 (s, 2H); HRMS calcd for C17H9N5O2SBr (M+H+): 425.9660, found 425.9646.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09446044B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-3067c214906643cfa6ab8ea7d70afe26 |
| 출처 메모 | uspto-grants-2016_09 |