Boc-Lys(Z)-OH → HCID 13132294, 화합물

HRID 621166노트

반응식

HRID 621166 반응식
[C:1]([O:5][C:6](=[O:18])[CH2:7][NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[C:19]([O:23][C:24]([NH:26][C@H:27]([C:43](O)=[O:44])[CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:1]([O:5][C:6](=[O:18])[CH2:7][N:8]([C:43](=[O:44])[C@H:27]([CH2:28][CH2:29][CH2:30][CH2:31][NH:32][C:33]([O:35][CH2:36][C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)=[O:34])[NH:26][C:24]([O:23][C:19]([CH3:22])([CH3:20])[CH3:21])=[O:25])[CH:9]1[CH2:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:17]1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 2724765Boc-Lys(Z)-OHHCID 13132278tert-butyl 2-[(2,3-dihydro-1H-inden-2-yl)amino]acetate

생성물 1

HCID 13132294HCID 13132294, 화합물수율 69.3%

실험 절차

By reacting 8.2 g of N-(indan-2-yl)glycine tert-butyl ester with 13 g of Nα -tert-butoxycarbonyl-Nε -carbobenzoxy-L-lysine as in Reference Example 5, there is obtained 14 g of Nα -tert-butoxycarbonyl-Nε -carbobenzoxy-L-lysyl-N-(indan-2-yl)glycine tert-butyl ester as a colorless oil.

출처 및 근거

ORD 기록
ord-f71242741f9944ff8aa39e79aeed304a
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04822818

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