Water → HCID 53840232, 화합물

HRID 6212노트

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HRID 6212 반응식
[Br-].[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([P+](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:12]=1.[Li]CCCC.[OH:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][N:49]1[C:58]2[C:53](=[CH:54][C:55]([CH:59]=[CH:60][CH:61]=O)=[CH:56][CH:57]=2)[CH2:52][CH2:51][CH2:50]1.O>C1(C)C=CC=CC=1>[OH:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][N:49]1[C:58]2[C:53](=[CH:54][C:55]([CH:59]=[CH:60][CH:61]=[CH:17][C:14]3[CH:13]=[CH:12][C:11]([C:3]4[O:2][C:6]5[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=5[N:4]=4)=[CH:16][CH:15]=3)=[CH:56][CH:57]=2)[CH2:52][CH2:51][CH2:50]1

참가 물질

6

반응물 4

HCID 962WaterHCID 54151230HCID 54151230, 화합물HCID 867444264-(Benzoxazol-2-yl)tolyltriphenylphosphonium bromideHCID 178418339Butyllithium

생성물 1

HCID 53840232HCID 53840232, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

To a stirred mixture of 110 g (0.2 mole) of 4-(benzoxazol-2-yl)tolyltriphenylphosphonium bromide in toluene is added dropwise 0.2 mole of n-BuLi at room temperature. After 2 hours a solution of 28.7 g (0.1 mole) of 3-(N-hydroxyhexyl-1,2,3,4-tetrahydroquinolin-6-yl)acrolein in toluene is added dropwise to the mixture, and the reaction is stirred for 18 hours at room temperature. Water is added, and the solids are isolated by vacuum filtration, washed with 60% ethanol/water, and dried under vacuum. The product is purified by recrystallization from benzene.

후처리

  1. customthe solids are isolated by vacuum filtration
  2. washwashed with 60% ethanol/water
  3. customdried under vacuum
  4. customThe product is purified by recrystallization from benzene

출처 및 근거

ORD 기록
ord-56e0c8bc731e4aa9a568d920148f452a
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05247042

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