Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Dimethoxyaniline → 9-(3,5-Dimethoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Dimethoxyaniline | HCID 66301 | — |
| 반응물 | Potassium Bromide | HCID 253877 | — |
| 반응물 | HCID 178484237 | HCID 178484237 | — |
| 용매 | Dichloromethane ethylacetate | HCID 21226138 | — |
| 생성물 | 9-(3,5-Dimethoxyphenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile | HCID 71277769 | 98% |
반응 단계
Prepared from VII and 3,5-dimethoxyaniline. Flash chromatography eluent (DCM-EtOAc, 5:5). Yield: 98%; yellow solid; mp 248° C.; IR (KBr) νmax/cm−1 3242, 2940, 2837, 2223, 1711, 1647, 1578, 1455, 1419, 1383, 1357, 1306, 1265, 1205, 1144, 1058, 1046, 968, 943, 917, 833, 806; 1H NMR (300 MHz, DMSO-d6) δ 8.51 (d, 1H, J=9.0 Hz), 8.06 (s, 1H), 7.79 (d, 1H, J=9.0 Hz), 6.31 (m, 3H), 3.74 (s, 6H); HRMS calcd for C18H14N5O2S (M+H+): 364.0868, found 364.0856.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09446044B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-6633b56490f349b0be0f18ec1cd7ca91 |
| 출처 메모 | uspto-grants-2016_09 |