Benzenamine, 4-methoxy-3-nitro- → 9-(4-Methoxy-3-nitrophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

HRID 62133

반응식

HRID 62133 반응식
[C:1]([C:3]1[S:4][C:5]2[C:11]([C:12]#[N:13])=[C:10](/[N:14]=[CH:15]/[N:16](C)C)[CH:9]=[CH:8][C:6]=2[N:7]=1)#[N:2].[N+:19]([C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])N)([O-:21])=[O:20].[K+].[Br-]>C(Cl)Cl.CCOC(C)=O>[CH3:30][O:29][C:28]1[CH:27]=[CH:26][C:24]([NH:13][C:12]2[C:11]3[C:10](=[CH:9][CH:8]=[C:6]4[N:7]=[C:3]([C:1]#[N:2])[S:4][C:5]4=3)[N:14]=[CH:15][N:16]=2)=[CH:23][C:22]=1[N+:19]([O-:21])=[O:20]

참가 물질

5

반응물 3

HCID 123071Benzenamine, 4-methoxy-3-nitro-HCID 253877Potassium BromideHCID 178484237HCID 178484237, 화합물

생성물 1

HCID 712777709-(4-Methoxy-3-nitrophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile수율 61%

시약·촉매·용매 1

HCID 21226138Dichloromethane ethylacetate용매

실험 절차

Prepared from VII and 3-nitro-4-methoxyaniline. Flash chromatography eluent (DCM-EtOAc, 7:3). Yield: 61%; yellow solid; mp 200-260° C.; IR (KBr) νmax/cm−1 2226, 1644, 1523, 1459, 1346, 1267, 1191, 1155, 1075, 1015, 970, 928, 890, 822; 1H NMR (300 MHz, DMSO-d6) δ 8.47 (d, 1H, J=9.0 Hz), 8.26 (s, 1H), 7.97 (d, 1H, J=9.0 Hz), 7.70 (s, 2H), 7.32 (d, 1H, J=9.0 Hz), 3.93 (s, 3H); HRMS calcd for C17H11N6O3S (M+H+): 379.0613, found 379.0614.

출처 및 근거

ORD 기록
ord-623bf30e41ce4fd68b08f0d16d40103d
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09446044B2

연결된 노트

불러오는 중…