Water → 1-(2-Chloro-5-nitrophenyl)-2-(2,2-dimethylpropionyl)hydrazine

HRID 621369

반응식

HRID 621369 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][NH2:12].C(N(CC)CC)C.[C:20](Cl)(=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22].O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][NH:12][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 62493Pivaloyl chlorideHCID 4103137(2-Chloro-5-nitrophenyl)hydrazine

생성물 1

HCID 142806541-(2-Chloro-5-nitrophenyl)-2-(2,2-dimethylpropionyl)hydrazine수율 77.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-chloro-5-nitrophenylhydrazine (37.60 g) in dichloromethane (200 ml), triethylamine (22.27 g) and pivaloyl chloride (26.59 g) were added, and the resultant mixture was stirred at room temperature for 12 hours. The reaction mixture was combined with water. The dichloromethane layer was washed with water, dried and concentrated under reduced pressure to give 1-(2-chloro-5-nitrophenyl)-2-(2,2-dimethylpropionyl)hydrazine (42.23 g). m.p., 153.3° C.

후처리

  1. washThe dichloromethane layer was washed with water
  2. customdried
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-bfb826ccda3941b08c92bfee3f6fa0b7
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824465

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