Ammonia → 2-Isopropyl-5-oxo-1-imidazolidineacetamide

HRID 621599노트

반응식

HRID 621599 반응식
[CH3:1][CH:2]([CH:4]1[NH:8][CH2:7][C:6](=[O:9])[N:5]1[CH2:10][C:11]([O:13]CC)=O)[CH3:3].[NH3:16]>CO>[CH3:3][CH:2]([CH:4]1[NH:8][CH2:7][C:6](=[O:9])[N:5]1[CH2:10][C:11]([NH2:16])=[O:13])[CH3:1]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 14618022Ethyl 2-isopropyl-5-oxo-1-imidazolidineacetate

생성물 1

HCID 146180232-Isopropyl-5-oxo-1-imidazolidineacetamide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

An ice cold solution of 3.8 g (0.018 mol) of ethyl 2-(1-methylethyl)-5-oxo-1-imidazolidineacetate in 100 ml of methanol was saturated with gaseous ammonia. The solution was stirred at room temperature overnight and the solvent was evaporated under reduced pressure, to give 2-(1-methylethyl)-5-oxo-1-imidazolidineacetamide (3.4 g) as a viscous oil (Rf 0.33; ethyl acetate/methanol 6:4; silica gel plates). Monohydrate of sulphate salt m.p. 64° C. resolidifying with final decomposition at 114°-118° C.

후처리

  1. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-92cbabc2112f4048ad0f955073673e94
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824861

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