Acetyl chloride → N-[2-(Acetyloxy)ethyl]-N,N-dimethyldodecan-1-aminium bromide

HRID 621607노트

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HRID 621607 반응식
[Br-:1].[CH2:2]([N+:14]([CH3:19])([CH3:18])[CH2:15][CH2:16][OH:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].C(=O)([O-])[O-].[Na+].[Na+].[C:26](Cl)(=[O:28])[CH3:27]>CC(C)=O>[Br-:1].[CH2:2]([N+:14]([CH3:19])([CH3:18])[CH2:15][CH2:16][O:17][C:26](=[O:28])[CH3:27])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 10340Sodium CarbonateHCID 814861-Dodecanaminium, N-(2-hydroxyethyl)-N,N-dimethyl-, bromide (1:1)

생성물 1

HCID 13914766N-[2-(Acetyloxy)ethyl]-N,N-dimethyldodecan-1-aminium bromide

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
60 °C

실험 절차

In a reaction vessel was placed 13.14 grams of dodecyl dimethyl 2-hydroxyethyl ammonium bromide, 21.22 grams of acetone solvent and 4.72 grams of sodium carbonate. While stirring under nitrogen, 3.27 grams of acetyl chloride was added dropwise. Gas evolution occurred. The mixture was then refluxed (approx. 60° C.) for 6 hours. The solvent was removed under vacuum. The residue was extracted with isopropanol to dissolve the quat and the solution was filtered hot to removed sodium chloride and sodium carbonate. The filtrate was evaporated under vacuum leaving as the product dodecyl dimethyl acetyloxyethyl ammonium bromide.

후처리

  1. customIn a reaction vessel was placed
  2. customThe solvent was removed under vacuum
  3. extractionThe residue was extracted with isopropanol
  4. dissolutionto dissolve the quat
  5. filtrationthe solution was filtered hot
  6. customto removed sodium chloride and sodium carbonate
  7. customThe filtrate was evaporated under vacuum

출처 및 근거

ORD 기록
ord-ad80dc4138404862b21d909f7f27b461
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824867

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