Sodium Chloride → HCID 19934656, 화합물

HRID 621634노트

반응식

HRID 621634 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([O:16][CH3:17])[CH:4]=1.[C-:18]#[N:19].[Na+].[Cl-].[Na+]>CN(C)C=O>[C:18]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([O:16][CH3:17])[CH:4]=1)#[N:19]

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 8929Sodium CyanideHCID 19934631HCID 19934631, 화합물

생성물 1

HCID 19934656HCID 19934656, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
30 °C

실험 절차

The 1-chloromethyl-3-methoxy-4-phenylthiobenzene obtained above is dissolved in N,N-dimethylformamide (200 ml), and thereto is added finely divided sodium cyanide (7.34 g), and the mixture is stirred at 30° C. for 14 hours. To the reaction mixture are added saturated aqueous sodium chloride solution (300 ml) and ice water (300 ml), and the mixture is extracted with ethyl acetate (300 ml×3). The combined extracts are washed with saturated aqueous sodium chloride solution (200 ml×3) and dried over anhydrous sodium sulfate to give 1-cyanomethyl-3-methoxy-4-phenylthiobenzene. benzene.

후처리

  1. extractionthe mixture is extracted with ethyl acetate (300 ml×3)
  2. washThe combined extracts are washed with saturated aqueous sodium chloride solution (200 ml×3)
  3. dry with materialdried over anhydrous sodium sulfate

출처 및 근거

ORD 기록
ord-61188dab6b6a41dea3e4c1e5783cfd8a
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824834

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