Thionyl Chloride → 1-(Chloromethyl)-4-(phenylthio)benzene

HRID 621637

반응식

HRID 621637 반응식
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][CH:4]=1.S(Cl)([Cl:18])=O>C(Cl)Cl>[Cl:18][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 80593p-(Phenylthio)benzyl alcohol

생성물 1

HCID 710221-(Chloromethyl)-4-(phenylthio)benzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The 1-hydroxymethyl-4-phenylthiobenzene (3.0 g) is dissolved in methylene chloride (15 ml), and thereto is added with stirring thionyl chloride (1.5 ml) under ice cooling. The mixture is stirred for one hour, and the reaction mixture is washed with ice water (10 ml×3), and thereto is added methylene chloride (50 ml). The mixture is washed in order with 5% aqueous sodium hydrogen carbonate solution (5 ml×3) and saturated aqueous sodium chloride solution (30 ml×2), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 1-chloromethyl-4-phenylthiobenzene (3.0 g).

후처리

  1. washthe reaction mixture is washed with ice water (10 ml×3)
  2. additionis added methylene chloride (50 ml)
  3. washThe mixture is washed in order with 5% aqueous sodium hydrogen carbonate solution (5 ml×3) and saturated aqueous sodium chloride solution (30 ml×2)
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9869be6f4db74c7c9036d7efba84631d
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824834

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