참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Desipramine Hydrochloride | HCID 65327 | — |
| 반응물 | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 14750714 | HCID 14750714 | 62% |
반응 단계
Freshly prepared nicotinoyl chloride hydrochloride (0.55 g, 0.003 mol) was suspended in methylene chloride (12 ml) cooled to 5° C. and sodium bicarbonate (0.053 g, 0.0063 mol) was added. After 5 minutes, desipramine hydrochloride (0.75 g, 0.0025 mol) was added and the mixture was stirred for 3 hours at 5° C. The sodium chloride was removed by filtration and the organic solution was extracted with aqueous sodium bicarbonate, dried over sodium sulfate, filtered through Celite™ and concentrated. Ethyl ether (5 ml) was added to the oily residue and white crystals formed. Yield 62% (0.58 g), m.p. 84°-86° C. The product has the formula: ##STR1616##
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04824850 |
|---|
| 출처 데이터셋 | uspto-grants-1989_04 |
|---|
| ORD ID | ord-17821f5355284f8e935f4fa6162d6dfb |
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| 출처 메모 | uspto-grants-1989_04 |
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