Ethyl bromoacetate → HCID 14385110, 화합물

HRID 62170

반응식

HRID 62170 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][C:10]([Br:15])=[CH:9][CH:8]=3.[OH-].[K+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>CN(C)C=O.C(OCC)(=O)C>[Br:15][C:10]1[CH:9]=[CH:8][C:7]2[N:6]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:5]3[C:13]([C:12]=2[CH:11]=1)=[CH:14][C:2]([Br:1])=[CH:3][CH:4]=3

참가 물질

6

반응물 3

HCID 7748Ethyl bromoacetateHCID 14797Potassium HydroxideHCID 2748743,6-Dibromocarbazole

생성물 1

HCID 14385110HCID 14385110, 화합물수율 96.4%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 3,6-dibromocarbazole (325.0 mg, 1.0 mmol, 1 equiv) in anhydrous N,N-dimethylformamide (5 mL) was added crushed KOH (67.3 mg, 1.2 mmol, 1.2 equiv). The mixture was stirred for 30 minutes. Ethyl bromoacetate (277.2 μL, 2.5 mmol, 2.5 equiv) was added into the mixture and it was stirred at room temperature overnight. The reaction crude was diluted with ethyl acetate (30 mL) and washed with 1M HCl and water. The organic layer was dried with MgSO4 and the concentrated to afford 396.3 mg white solid as product (96.4%).

후처리

  1. stirringwas stirred at room temperature overnight
  2. customThe reaction crude
  3. washwashed with 1M HCl and water
  4. dry with materialThe organic layer was dried with MgSO4
  5. concentrationthe concentrated

출처 및 근거

ORD 기록
ord-13705633f74f46e1b213b36410727bb9
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09446022B2

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