HCID 12798005, 화합물 → HCID 21243579, 화합물

HRID 621723노트

반응식

HRID 621723 반응식
OC1C=CC=C2C=1C(C#N)=CN2.[O:13]1[CH2:28][CH:14]1[CH2:15][O:16][C:17]1[CH:25]=[CH:24][CH:23]=[C:22]2[C:18]=1[C:19]([C:26]#[N:27])=[CH:20][NH:21]2.[CH2:29]([O:32][C:33]1[CH:42]=[CH:41][CH:40]=[CH:39][C:34]=1[O:35][CH2:36][CH2:37][NH2:38])[CH:30]=[CH2:31]>>[OH:13][CH:14]([CH2:28][NH:38][CH2:37][CH2:36][O:35][C:34]1[CH:39]=[CH:40][CH:41]=[CH:42][C:33]=1[O:32][CH2:29][CH:30]=[CH2:31])[CH2:15][O:16][C:17]1[CH:25]=[CH:24][CH:23]=[C:22]2[C:18]=1[C:19]([C:26]#[N:27])=[CH:20][NH:21]2

참가 물질

4

반응물 3

HCID 12798005HCID 12798005, 화합물HCID 131869494-hydroxy-1H-indole-3-carbonitrileHCID 21243576HCID 21243576, 화합물

생성물 1

HCID 21243579HCID 21243579, 화합물

실험 절차

Compounds of general formula (I) can be further reacted by known methods, for example by saponification and decarboxylation to give 4-hydroxyindole or 4-hydroxy-6-methylindole, or by aminolysis and dehydration to give 4-hydroxy-3-cyanoindole or 4-hydroxy-3-cyano-6-methyl-indole, which, by reaction with epichlorohydrin and alkylamino derivatives, give aminopropanols with useful pharmacological properties (see Federal Republic of Germany Patent Specification Nos. 25 08 251; 27 37 630; 29 05 877 and 30 30 047). However, compounds of general formula (I) can also be reacted to give aminopropanol derivatives directly, whereafter the compounds obtained are subsequently changed. Thus, for example, from 4-hydroxy-3-cyanoindole (see Federal Republic of German Patent Specification No. 30 29 980) there is obtained 4-(2,3-epoxypropoxy)-3-cyanoindole which is reacted with 2-(2-allyloxyphenoxy)-ethylamine to give the pharmacologically effective 4-{2-hydroxy-3-[2-(2-allyloxyphenoxy)-ethylamino]-propoxy}-3-cyanoindole (see Example 3h) of Federal Republic of German Patent Specification No. 30 30 047).

후처리

  1. customwhereafter the compounds obtained

출처 및 근거

ORD 기록
ord-252d98420e03413eb1f3ae458ba758c7
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824965

반응 노트

불러오는 중…