Triacetoxyperiodinane → HCID 58065823, 화합물

HRID 62208노트

반응식

HRID 62208 반응식
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[Br:23][C:24]1[CH:25]=[CH:26][C:27]2[N:28]([CH2:38][CH:39]([OH:48])[CH2:40][O:41][C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[C:29]3[C:34]([C:35]=2[CH:36]=1)=[CH:33][C:32]([Br:37])=[CH:31][CH:30]=3>ClCCl.CCOC(C)=O>[Br:23][C:24]1[CH:25]=[CH:26][C:27]2[N:28]([CH2:38][C:39](=[O:48])[CH2:40][O:41][C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=3)[C:29]3[C:34]([C:35]=2[CH:36]=1)=[CH:33][C:32]([Br:37])=[CH:31][CH:30]=3

참가 물질

5

반응물 2

HCID 159087TriacetoxyperiodinaneHCID 468517151-(3,6-dibromo-9H-carbazol-9-yl)-3-phenoxypropan-2-ol

생성물 1

HCID 58065823HCID 58065823, 화합물수율 74%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

Dess-Martin periodinane (58.2 mg, 0.137 mmol) was charged to a solution of the title compound of Example 3b (45.0 mg, 0.095 mmol) in dichloromethane (1.0 ml, 0.095 M). After two hours the reaction mixture was diluted with EtOAc and washed with saturated sodium thiosulfate solution, water and brine. The organic layer was dried over Na2SO4, filtered and condensed. The crude product was used without additional purification. Yield=74%

후처리

  1. washwashed with saturated sodium thiosulfate solution, water and brine
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. customcondensed
  5. customThe crude product was used without additional purification

출처 및 근거

ORD 기록
ord-e0e0765d791c4e44bee6a024f796035b
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09446042B2

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