Hydrazine → 6-Bromophthalazin-1(2h)-one

HRID 622123

반응식

HRID 622123 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:7](=O)[O:6][CH:5]2O.[NH2:13][NH2:14]>C(O)(C)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:7](=[O:6])[NH:14][N:13]=[CH:5]2

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 142348425-bromo-3-hydroxy-3H-isobenzofuran-1-one

생성물 1

HCID 115359186-Bromophthalazin-1(2h)-one

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

5-Bromo-3-hydroxyphthalide (49 gm) was slurred in 200 ml isopropanol. Hydrazine (20 ml) was added and the mixture refluxed for 2 hours. The reaction mixture was allowed to cool and the product filtered off, washed with isopropanol and dried. The product weighed 46.8 gm and melted at 280°-283° C.

후처리

  1. temperaturethe mixture refluxed for 2 hours
  2. temperatureto cool
  3. filtrationthe product filtered off
  4. washwashed with isopropanol
  5. customdried

출처 및 근거

ORD 기록
ord-26892674c85c4488bb0acbd772a4af2f
출처 데이터셋
uspto-grants-1988_09
특허 번호
US04769369

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