Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 1-(N,N-dibutylaminocarbonyloxy)-2-phenylphenanthroimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Dibutylcarbamoyl chloride | HCID 83371 | — |
| 반응물 | 1-Hydroxy-2-phenylphenanthroimidazole | HCID 86742423 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(N,N-dibutylaminocarbonyloxy)-2-phenylphenanthroimidazole | HCID 86742422 | — |
반응 단계
10 parts of 1-hydroxy-2-phenylphenanthroimidazole, 8 parts of anhydrous potassium carbonate and 6.7 parts of N,N-dibutylcarbamyl chloride in 100 parts of tetrahydrofuran are refluxed for 5 hours. 100 parts of water and 200 parts of ethyl acetate are then added. The organic phase is washed with water, dried over sodium sulfate and evaporated down under reduced pressure. When the residue is left to stand, 6.6 parts of a solid which has a melting point of 120° C. and is pure according to thin layer chromatography are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04770976 |
| 출처 데이터셋 | uspto-grants-1988_09 |
| ORD ID | ord-c08a6d890a5b4754bc072ba3271cb4fa |
| 출처 메모 | uspto-grants-1988_09 |