N,N-Dimethylmethanesulphonamide → 1-(2-amino-5-methoxyphenyl)-2-(N,N-dimethylsulphamoyl)ethanone

반응식

[CH3:1][N:2]([CH3:7])[S:3]([CH3:6])(=[O:5])=[O:4].C([Li])CCC.[NH2:13][C:14]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:15]=1[C:16](OCC)=[O:17]>>[NH2:13][C:14]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:15]=1[C:16](=[O:17])[CH2:6][S:3](=[O:5])(=[O:4])[N:2]([CH3:7])[CH3:1]

참가 물질

반응물 3

HCID 70191N,N-Dimethylmethanesulphonamide

HCID 21291483Ethyl 2-amino-5-methoxybenzoate

HCID 178418339Butyllithium

생성물 1

HCID 212915061-(2-amino-5-methoxyphenyl)-2-(N,N-dimethylsulphamoyl)ethanone

실험 절차

In a similar manner to that described in Example 12(a), N,N-dimethylmethanesulphonamide was reacted with n-butyl lithium and the product was reacted with ethyl 2-amino-5-methoxybenzoate to give the novel compound 1-(2-amino-5-methoxyphenyl)-2-(N,N-dimethylsulphamoyl)ethanone, m.p. 198°-200°.

출처 및 근거

ORD 기록: ord-87820ce0e9544d7c91daa3f8a707e23e
출처 데이터셋: uspto-grants-1988_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04772614

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