N,N-Dimethylmethanesulphonamide → 1-(2-amino-4-chloro-5-methoxyphenyl)-2-(N,N-dimethylsulphamoyl)ethanone

HRID 622697

반응식

HRID 622697 반응식
[CH3:1][N:2]([CH3:7])[S:3]([CH3:6])(=[O:5])=[O:4].C([Li])CCC.[NH2:13][C:14]1[CH:24]=[C:23]([Cl:25])[C:22]([O:26][CH3:27])=[CH:21][C:15]=1[C:16](OCC)=[O:17]>>[NH2:13][C:14]1[CH:24]=[C:23]([Cl:25])[C:22]([O:26][CH3:27])=[CH:21][C:15]=1[C:16](=[O:17])[CH2:6][S:3](=[O:5])(=[O:4])[N:2]([CH3:7])[CH3:1]

참가 물질

4

반응물 3

HCID 70191N,N-DimethylmethanesulphonamideHCID 21291464Ethyl 2-amino-4-chloro-5-methoxybenzoateHCID 178418339Butyllithium

생성물 1

HCID 212914951-(2-amino-4-chloro-5-methoxyphenyl)-2-(N,N-dimethylsulphamoyl)ethanone

실험 절차

In a similar manner to tht described in Example 12(a), N,N-dimethylmethanesulphonamide was reacted with n-butyl lithium and the product reacted with ethyl 2-amino-4-chloro-5-methoxybenzoate to give the novel compound 1-(2-amino-4-chloro-5-methoxyphenyl)-2-(N,N-dimethylsulphamoyl)ethanone, m.p. 59°-62°.

출처 및 근거

ORD 기록
ord-d5e783f4a51a4bd9b76015ea68f29918
출처 데이터셋
uspto-grants-1988_09
특허 번호
US04772614

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