참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl orthoformate | HCID 31214 | — |
| 반응물 | 1-(4-(3-Aminophenyl)thiazol-2-yl)guanidine | HCID 178512611 | — |
| 촉매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | HCID 178482140 | HCID 178482140 | — |
반응 단계
A mixture of 9.3 g (0.04 mole) of 3-(2-guanidino-4-thiazolyl)benzeneamine, 20 ml of triethylorthoformate, and 2 drops of trifluoroacetic acid is stirred at reflux for 5 hours after which it is concentrated in vacuo. The residue is dissolved in 20 ml of ethanol, the solution cooled to 0° C. and then treated with excess sodium borohydride. The mixture is allowed to warm to room temperature, then stirred at reflux for 4 hours. Upon concentration in vacuo the residue is partitioned between water and dichloromethane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04772622 |
|---|
| 출처 데이터셋 | uspto-grants-1988_09 |
|---|
| ORD ID | ord-bf26f55371854a828c4f5bb935c679d5 |
|---|
| 출처 메모 | uspto-grants-1988_09 |
|---|
