Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Methanesulfonic Acid | HCID 6395 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Boc-Ser(Bzl)-Tyr(Bzl)-OBzl | HCID 14012223 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 생성물 | N2-((tert-Butoxy)carbonyl)-L-asparagine | HCID 82035 | — |
반응 단계
[α]D20 =-16.7° (C=1, DMF) (B) From 133.2 g of DP-2, 100 g of methansulfonic acid, 84.4 g of Et3N, 36.7 g of HOBt.H2O, 55.7 g of Boc-Asn-OH and 37.2 g of WSC, 157 g (100%) of DP-3 are obtained by employing the same technique described in example I-7.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04774319 |
| 출처 데이터셋 | uspto-grants-1988_09 |
| ORD ID | ord-3cec2931050a4df88a6f2bd44591a367 |
| 출처 메모 | uspto-grants-1988_09 |