Tert-Butylamine → N-tert-butyl-2-amino-3,5-dichlorobenzamide

HRID 623278노트

반응식

HRID 623278 반응식
CO[C:3](=[O:13])[C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[C:5]=1[NH2:12].[C:14]([NH2:18])([CH3:17])([CH3:16])[CH3:15]>CO>[C:14]([NH:18][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[C:5]=1[NH2:12])([CH3:17])([CH3:16])[CH3:15]

참가 물질

4

반응물 2

HCID 6385Tert-ButylamineHCID 613050Methyl 2-amino-3,5-dichlorobenzoate

생성물 1

HCID 118496623N-tert-butyl-2-amino-3,5-dichlorobenzamide수율 90.4%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
64 °C

실험 절차

To a 100 mL round-bottom flask, 0.1 mol of 2-amino-3,5-dichlorobenzoic acid methyl ester having a structure as shown in VIII-1, 100 mL of methanol, and 0.4 mol of tert-butylamine were added, heated to 64° C. and reacted for 5 hours, after treatment 23.5 grams of N-tert-butyl-2-amino-3,5-dichlorobenzamide having a structural formula of III-1 was obtained, and the yield was 90.4%;

후처리

  1. additionwere added
  2. customreacted for 5 hours

출처 및 근거

ORD 기록
ord-d84848f7159b4522a4d7d69ea5449e08
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09301529B2

반응 노트

불러오는 중…