Methanol → HCID 178501206, 화합물

HRID 623383노트

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HRID 623383 반응식
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]1.O=S(Cl)Cl.[CH3:15]O>>[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([O:10][CH3:15])=[O:9])[CH2:4][CH2:3]1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178511566HCID 178511566, 화합물

생성물 1

HCID 178501206HCID 178501206, 화합물

실험 절차

A suspension of cis-4-aminocyclohexanecarboxylic acid (5.0 g, 34.9 mmol) in methanol (50 mL) was stirred at room temperature and SOCl2 (7.1 mL, 98.4 mmol) was added dropwise over 20 minutes, causing the solid to dissolve. The solution was stirred overnight and the methanol was then removed under reduced pressure. The residual solid was triturated with diethyl ether and air-dried and the title compound obtained as an off-white powder (6.0 g).

후처리

  1. dissolutionto dissolve
  2. stirringThe solution was stirred overnight
  3. customthe methanol was then removed under reduced pressure
  4. customThe residual solid was triturated with diethyl ether
  5. customair-dried

출처 및 근거

ORD 기록
ord-3d2293090a614a479efad5ab4c8a7327
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09302984B2

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