Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Hydroxyiminomethyl)quinolin-8-ol → 2-(Aminomethyl)quinolin-8-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Hydroxyiminomethyl)quinolin-8-ol | HCID 604733 | — |
| 촉매 | HCID 178418390 | HCID 178418390 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(Aminomethyl)quinolin-8-ol | HCID 599967 | 82% |
반응 단계
8-Hydroxy-quinoline-2-carboxaldehyde oxime D1 (167 mg, 0.888 mmol) and MeOH (50 mL) was treated under hydrogenolysis conditions (atmospheric H2, catalytic 10% Pd/carbon) at RT. After 4 h, the catalyst was filtered off and the volatiles removed which afforded 2-aminomethyl-quinolin-8-ol E1 as a light brown solid (126 mg, 82%); spectral data of this compound are given in Table 2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09302993B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-7056e7ae34984f5c9d181c58b9c74d53 |
| 출처 메모 | uspto-grants-2016_04 |