Hydride → 3-Pyridinemethanol, 5-chloro-6-(2,2,2-trifluoroethoxy)-

HRID 623454노트

반응식

HRID 623454 반응식
[Cl:1][C:2]1[C:3]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](OC)=[O:8].[H-]>>[Cl:1][C:2]1[CH:11]=[C:6]([CH2:7][OH:8])[CH:5]=[N:4][C:3]=1[O:12][CH2:13][C:14]([F:15])([F:16])[F:17]

참가 물질

3

반응물 2

HCID 166653HydrideHCID 67509641HCID 67509641, 화합물

생성물 1

HCID 612563313-Pyridinemethanol, 5-chloro-6-(2,2,2-trifluoroethoxy)-수율 78%

실험 절차

The title compound is prepared in 78% yield (210 mg, a white solid) from methyl 5-chloro-6-(2,2,2-trifluoroethoxy)nicotinate (300 mg, 1.1 mmol, Step-1) and diisobutylalminium hydride (1.0 M in hexane, 2.4 mL, 2.4 mmol) by the similar manner in Step-3 of Amine-4.

출처 및 근거

ORD 기록
ord-14a2c3c807bd493783a0131c45bfe29f
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09302991B2

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