6-Bromopyridine-3-carbonitrile → 6-(2-(Trifluoromethoxy)ethoxy)nicotinonitrile

반응식

Br[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[F:10][C:11]([F:17])([F:16])[O:12][CH2:13][CH2:14][OH:15]>>[F:10][C:11]([F:17])([F:16])[O:12][CH2:13][CH2:14][O:15][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 50057186-Bromopyridine-3-carbonitrile

HCID 179516872-(Trifluoromethoxy)ethan-1-ol

생성물 1

HCID 675107096-(2-(Trifluoromethoxy)ethoxy)nicotinonitrile수율 95%

실험 절차

The title compound is prepared in 95% yield (509 mg, colorless oil) from 6-bromonicotinonitrile (422 mg, 2.31 mmol) and 2-(trifluoromethoxy)ethanol (300 mg, 2.31 mmol) by the similar manner in Step-1 of Amine-101.

출처 및 근거

ORD 기록: ord-f77dfa4bbe0043d3a105b95e9fc27b47
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09302991B2

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