2-Amino-6-methylpyrimidine-4-carboxylic acid → 2-amino-N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-methylpyrimidine-4-carboxamide

HRID 623601노트

반응식

HRID 623601 반응식
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH:15]([NH2:17])[CH3:16])[CH:6]=[N:7][C:8]=1[O:9][CH2:10][C:11]([F:14])([F:13])[F:12].[NH2:18][C:19]1[N:24]=[C:23]([C:25](O)=[O:26])[CH:22]=[C:21]([CH3:28])[N:20]=1>>[NH2:18][C:19]1[N:24]=[C:23]([C:25]([NH:17][CH:15]([C:5]2[CH:6]=[N:7][C:8]([O:9][CH2:10][C:11]([F:12])([F:13])[F:14])=[C:3]([Cl:2])[CH:4]=2)[CH3:16])=[O:26])[CH:22]=[C:21]([CH3:28])[N:20]=1

참가 물질

3

반응물 2

HCID 2466462-Amino-6-methylpyrimidine-4-carboxylic acidHCID 675090891-(5-Chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride

생성물 1

HCID 675107842-amino-N-(1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethyl)-6-methylpyrimidine-4-carboxamide수율 52%

실험 절차

The title compound is prepared in 52% yield (146 mg, clear pale yellow oil) from (+)-1-(5-chloro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)ethanamine hydrochloride (210 mg, 0.72 mmol, Amine-5, single enantiomer) and 2-amino-6-methylpyrimidine-4-carboxylic acid (110 mg, 0.72 mmol) by the similar manner in Step-1 of Example 8.

출처 및 근거

ORD 기록
ord-e2b3362cfe5b404ea2bf206ca9add54a
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09302991B2

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