[3-(2,4-dihydroxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-(4-morpholin-4-yl-phenyl)-carbamic acid t-butyl ester → 4-Isopropyl-6-[5-(4-morpholin-4-yl-phenylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diol

HRID 623676노트

반응식

HRID 623676 반응식
C(OC(=O)[N:7]([C:20]1[N:21]([C:25]2[CH:30]=[C:29]([CH:31]([CH3:33])[CH3:32])[C:28]([OH:34])=[CH:27][C:26]=2[OH:35])[N:22]=[N:23][CH:24]=1)[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[CH:31]([C:29]1[CH:30]=[C:25]([N:21]2[C:20]([NH:7][C:8]3[CH:9]=[CH:10][C:11]([N:14]4[CH2:15][CH2:16][O:17][CH2:18][CH2:19]4)=[CH:12][CH:13]=3)=[CH:24][N:23]=[N:22]2)[C:26]([OH:35])=[CH:27][C:28]=1[OH:34])([CH3:33])[CH3:32]

참가 물질

3

반응물 1

HCID 131735186[3-(2,4-dihydroxy-5-isopropyl-phenyl)-3H-[1,2,3]triazol-4-yl]-(4-morpholin-4-yl-phenyl)-carbamic acid t-butyl ester

생성물 1

HCID 574046064-Isopropyl-6-[5-(4-morpholin-4-yl-phenylamino)-[1,2,3]triazol-1-yl]-benzene-1,3-diol수율 45%

시약·촉매·용매 1

HCID 21863450Trifluoroacetic acid methylene chloride용매

실험 절차

A solution of the intermediate from Step E in DCM/TFA (1/1 5 ml) was stirred for 12 hours at RT. The reaction mixture was concentrated under reduced pressure and the crude reaction mixture was purified by column chromatography (DCM/MeOH: 95/5). The title compound was obtained as slightly brown solid.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe crude reaction mixture
  3. customwas purified by column chromatography (DCM/MeOH: 95/5)

출처 및 근거

ORD 기록
ord-6104a9e4cc994815ba91308fc49594dd
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09302998B2

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