6-bromo-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-2(1H)-one → 6-Bromo-2-chloro-3-phenoxy-4-(trifluoromethyl)quinoline

HRID 623966노트

반응식

HRID 623966 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=O)[C:6]([O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[C:5]2[C:20]([F:23])([F:22])[F:21].BrC1C=C2C(=CC=1)NC(=O)C(OC1C=CC([Cl:43])=CC=1)=C2C(F)(F)F>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:43])[C:6]([O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[C:5]2[C:20]([F:23])([F:22])[F:21]

참가 물질

3

반응물 2

HCID 867154486-bromo-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-2(1H)-one3회HCID 867154516-Bromo-3-phenoxy-4-(trifluoromethyl)quinolin-2(1H)-one

생성물 1

HCID 867154526-Bromo-2-chloro-3-phenoxy-4-(trifluoromethyl)quinoline

실험 절차

The title compound was prepared using 6-bromo-3-phenoxy-4-(trifluoromethyl)quinolin-2(1H)-one (Intermediate 8, step a) in place of 6-bromo-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-2(1H)-one (Intermediate 7, step c) according to the procedure described in Intermediate 7, step d.

출처 및 근거

ORD 기록
ord-3dad8c92e4cc462a88c894c217c070dc
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303015B2

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