N-Ethylaniline → 6-Bromo-3-(ethyl(phenyl)amino)-4-hydroxyquinolin-2(1H)-one

반응식

[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2].FC(F)(F)S([O-])(=O)=O.[Br:18][C:19]1[CH:20]=[C:21]2[C:26](=[CH:27][CH:28]=1)[NH:25][C:24](=[O:29])[C:23]([I+]C1C=CC=CC=1)=[C:22]2[OH:37]>>[Br:18][C:19]1[CH:20]=[C:21]2[C:26](=[CH:27][CH:28]=1)[NH:25][C:24](=[O:29])[C:23]([N:3]([CH2:1][CH3:2])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[C:22]2[OH:37]

참가 물질

반응물 2

HCID 7670N-Ethylaniline

HCID 86715456(6-Bromo-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)(phenyl) iodoniumtrifluoromethane sulfonate

생성물 1

HCID 867154606-Bromo-3-(ethyl(phenyl)amino)-4-hydroxyquinolin-2(1H)-one

실험 절차

The title compound was prepared using N-ethylaniline in place of aniline according to the procedure of Intermediate 11, step c except the crude solid was purified by flash column chromatography (silica gel, 50% EtOAc-Heptane), affording the title compound.

후처리

customThe title compound was prepared
customwas purified by flash column chromatography (silica gel, 50% EtOAc-Heptane)

출처 및 근거

ORD 기록: ord-7cf644638eaa42d2960f792c10d0bc93
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09303015B2

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