1-(2-(5,6-dimethoxyindolin-1-yl)ethyl)-1H-pyrazol-4-amine → 1-[2-(5,6-Dimethoxy-indol-1-yl)-ethyl]-1H-pyrazol-4-ylamine

HRID 624019노트

반응식

HRID 624019 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]([CH2:14][CH2:15][N:16]1[CH:20]=[C:19]([NH2:21])[CH:18]=[N:17]1)[CH2:7][CH2:6]2>CC(C)=O.O=[Mn]=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]([CH2:14][CH2:15][N:16]1[CH:20]=[C:19]([NH2:21])[CH:18]=[N:17]1)[CH:7]=[CH:6]2

참가 물질

4

반응물 1

HCID 682827781-(2-(5,6-dimethoxyindolin-1-yl)ethyl)-1H-pyrazol-4-amine

생성물 1

HCID 682827821-[2-(5,6-Dimethoxy-indol-1-yl)-ethyl]-1H-pyrazol-4-ylamine

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 180Acetone용매2회

실험 절차

A solution of 1-(2-(5,6-dimethoxyindolin-1-yl)ethyl)-1H-pyrazol-4-amine (1.36 g, 4.70 mmol) in acetone (10 mL) was added dropwise to a suspension of MnO2 (817 mg, 9.41 mmol) in aceton (10 mL). The resulting dark reaction mixture was stirred at rt overnight, then filtered over celite, washed with acetone and the filtrate was concentrated under reduced pressure. Purification was performed by FC (DCM/MeOH 98:2→95:5) to yield the title compound as a brown oil. LC-MS conditions B: tR=0.41 min, [M+H]+=287.18.

후처리

  1. customThe resulting dark reaction mixture
  2. filtrationfiltered over celite
  3. washwashed with acetone
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customPurification

출처 및 근거

ORD 기록
ord-f9add7a71c294a1c864bf4085d8aae89
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303023B2

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