1-[3-(2,3-Dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine → 1-(3-Indol-1-yl-propyl)-1H-pyrazol-4-ylamine

HRID 624024노트

반응식

HRID 624024 반응식
[N:1]1([CH2:10][CH2:11][CH2:12][N:13]2[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1>CC(C)=O.O=[Mn]=O>[N:1]1([CH2:10][CH2:11][CH2:12][N:13]2[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

참가 물질

4

반응물 1

HCID 682827791-[3-(2,3-Dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine

생성물 1

HCID 682831811-(3-Indol-1-yl-propyl)-1H-pyrazol-4-ylamine

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 180Acetone용매2회

실험 절차

A solution of 1-[3-(2,3-dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine (200 mg, 0.83 mmol) in acetone (1.0 mL) was added dropwise to a suspension of MnO2 (275 mg, 3.17 mmol) in acetone (2.0 mL). The resulting dark reaction mixture was stirred at rt overnight, then filtered over celite, washed with acetone and the solvent was removed under reduced pressure to yield the title compound which was used without further purification in the next step. LC-MS conditions B: tR=0.51 min, [M+H]+=241.20.

후처리

  1. customThe resulting dark reaction mixture
  2. filtrationfiltered over celite
  3. washwashed with acetone
  4. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-8fe1a24413b2403da50ad27fd985e3ea
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303023B2

반응 노트

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